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cometchip ® analysis  (Integrated Laboratory Systems Inc)

 
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    Structured Review

    Integrated Laboratory Systems Inc cometchip ® analysis
    DNA damage in human HepaRG™ cells measured using the alkaline <t>CometChip</t> ® assay. Cells were exposed to increasing concentrations of DNA damage-inducing (DDI; A–I) and non-DDI test chemicals (J–L) . Median % tail DNA is shown 4 h following the last exposure. The data are expressed as the median % tail DNA ± SE ( n = 4). Red bars represent Group 1 DDI chemicals, blue bars denote the Group 2 non-DDI chemical and the Group 3 potentially misleading positive chemicals. Diagonal lines indicate overtly cytotoxic concentrations. Note the difference in the scale of the y-axis for MMS, ENU, and ZDV due to the large magnitude of the response for these three DDI (Group 1) chemicals. * P < 0.05, ** P < 0.001 compared to matched vehicle control.
    Cometchip ® Analysis, supplied by Integrated Laboratory Systems Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cometchip ® analysis/product/Integrated Laboratory Systems Inc
    Average 90 stars, based on 1 article reviews
    cometchip ® analysis - by Bioz Stars, 2026-05
    90/100 stars

    Images

    1) Product Images from "A Modern Genotoxicity Testing Paradigm: Integration of the High-Throughput CometChip® and the TGx-DDI Transcriptomic Biomarker in Human HepaRG™ Cell Cultures"

    Article Title: A Modern Genotoxicity Testing Paradigm: Integration of the High-Throughput CometChip® and the TGx-DDI Transcriptomic Biomarker in Human HepaRG™ Cell Cultures

    Journal: Frontiers in Public Health

    doi: 10.3389/fpubh.2021.694834

    DNA damage in human HepaRG™ cells measured using the alkaline CometChip ® assay. Cells were exposed to increasing concentrations of DNA damage-inducing (DDI; A–I) and non-DDI test chemicals (J–L) . Median % tail DNA is shown 4 h following the last exposure. The data are expressed as the median % tail DNA ± SE ( n = 4). Red bars represent Group 1 DDI chemicals, blue bars denote the Group 2 non-DDI chemical and the Group 3 potentially misleading positive chemicals. Diagonal lines indicate overtly cytotoxic concentrations. Note the difference in the scale of the y-axis for MMS, ENU, and ZDV due to the large magnitude of the response for these three DDI (Group 1) chemicals. * P < 0.05, ** P < 0.001 compared to matched vehicle control.
    Figure Legend Snippet: DNA damage in human HepaRG™ cells measured using the alkaline CometChip ® assay. Cells were exposed to increasing concentrations of DNA damage-inducing (DDI; A–I) and non-DDI test chemicals (J–L) . Median % tail DNA is shown 4 h following the last exposure. The data are expressed as the median % tail DNA ± SE ( n = 4). Red bars represent Group 1 DDI chemicals, blue bars denote the Group 2 non-DDI chemical and the Group 3 potentially misleading positive chemicals. Diagonal lines indicate overtly cytotoxic concentrations. Note the difference in the scale of the y-axis for MMS, ENU, and ZDV due to the large magnitude of the response for these three DDI (Group 1) chemicals. * P < 0.05, ** P < 0.001 compared to matched vehicle control.

    Techniques Used: Control

    Summary of CometChip ® analysis and TempO-Seq ® TGx-DDI classification results for 12 test chemicals.
    Figure Legend Snippet: Summary of CometChip ® analysis and TempO-Seq ® TGx-DDI classification results for 12 test chemicals.

    Techniques Used: Gene Expression

    Comparison of benchmark concentrations for CometChip ® (BMC CC ) and TGx-DDI biomarker genes (BMC TGx ).
    Figure Legend Snippet: Comparison of benchmark concentrations for CometChip ® (BMC CC ) and TGx-DDI biomarker genes (BMC TGx ).

    Techniques Used: Comparison, Biomarker Discovery

    Relationship between the BMCs of the CometChip ® data (BMC CC ) and the TGx-DDI biomarker genes (BMC TGx ) for the test chemicals that yielded positive hazard calls in both tests and could be modeled. Specifically, the BMC CC with a BMR of 1SD with two-sided 95% CIs are shown for the CometChip ® vs. median bootstrap BMC TGX (BMR of 1SD) with two-sided 95% CIs for the TGx-DDI biomarker classification endpoint. The BMCs for the agents that were classified as DDI from both approaches were within 10-fold. The two parallel black lines with intercepts of 1 and −1 on the double log10 scale represent a 10-fold deviation from the 1:1 line.
    Figure Legend Snippet: Relationship between the BMCs of the CometChip ® data (BMC CC ) and the TGx-DDI biomarker genes (BMC TGx ) for the test chemicals that yielded positive hazard calls in both tests and could be modeled. Specifically, the BMC CC with a BMR of 1SD with two-sided 95% CIs are shown for the CometChip ® vs. median bootstrap BMC TGX (BMR of 1SD) with two-sided 95% CIs for the TGx-DDI biomarker classification endpoint. The BMCs for the agents that were classified as DDI from both approaches were within 10-fold. The two parallel black lines with intercepts of 1 and −1 on the double log10 scale represent a 10-fold deviation from the 1:1 line.

    Techniques Used: Biomarker Discovery



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    DNA damage in human HepaRG™ cells measured using the alkaline <t>CometChip</t> ® assay. Cells were exposed to increasing concentrations of DNA damage-inducing (DDI; A–I) and non-DDI test chemicals (J–L) . Median % tail DNA is shown 4 h following the last exposure. The data are expressed as the median % tail DNA ± SE ( n = 4). Red bars represent Group 1 DDI chemicals, blue bars denote the Group 2 non-DDI chemical and the Group 3 potentially misleading positive chemicals. Diagonal lines indicate overtly cytotoxic concentrations. Note the difference in the scale of the y-axis for MMS, ENU, and ZDV due to the large magnitude of the response for these three DDI (Group 1) chemicals. * P < 0.05, ** P < 0.001 compared to matched vehicle control.
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    Image Search Results


    DNA damage in human HepaRG™ cells measured using the alkaline CometChip ® assay. Cells were exposed to increasing concentrations of DNA damage-inducing (DDI; A–I) and non-DDI test chemicals (J–L) . Median % tail DNA is shown 4 h following the last exposure. The data are expressed as the median % tail DNA ± SE ( n = 4). Red bars represent Group 1 DDI chemicals, blue bars denote the Group 2 non-DDI chemical and the Group 3 potentially misleading positive chemicals. Diagonal lines indicate overtly cytotoxic concentrations. Note the difference in the scale of the y-axis for MMS, ENU, and ZDV due to the large magnitude of the response for these three DDI (Group 1) chemicals. * P < 0.05, ** P < 0.001 compared to matched vehicle control.

    Journal: Frontiers in Public Health

    Article Title: A Modern Genotoxicity Testing Paradigm: Integration of the High-Throughput CometChip® and the TGx-DDI Transcriptomic Biomarker in Human HepaRG™ Cell Cultures

    doi: 10.3389/fpubh.2021.694834

    Figure Lengend Snippet: DNA damage in human HepaRG™ cells measured using the alkaline CometChip ® assay. Cells were exposed to increasing concentrations of DNA damage-inducing (DDI; A–I) and non-DDI test chemicals (J–L) . Median % tail DNA is shown 4 h following the last exposure. The data are expressed as the median % tail DNA ± SE ( n = 4). Red bars represent Group 1 DDI chemicals, blue bars denote the Group 2 non-DDI chemical and the Group 3 potentially misleading positive chemicals. Diagonal lines indicate overtly cytotoxic concentrations. Note the difference in the scale of the y-axis for MMS, ENU, and ZDV due to the large magnitude of the response for these three DDI (Group 1) chemicals. * P < 0.05, ** P < 0.001 compared to matched vehicle control.

    Article Snippet: The chemical exposures in HepaRGTM cells, the cell viability studies, and the paired high-throughput CometChip ® analysis were conducted at Integrated Laboratory Systems, Inc. (ILS; Research Triangle Park, Durham, NC, USA).

    Techniques: Control

    Summary of CometChip ® analysis and TempO-Seq ® TGx-DDI classification results for 12 test chemicals.

    Journal: Frontiers in Public Health

    Article Title: A Modern Genotoxicity Testing Paradigm: Integration of the High-Throughput CometChip® and the TGx-DDI Transcriptomic Biomarker in Human HepaRG™ Cell Cultures

    doi: 10.3389/fpubh.2021.694834

    Figure Lengend Snippet: Summary of CometChip ® analysis and TempO-Seq ® TGx-DDI classification results for 12 test chemicals.

    Article Snippet: The chemical exposures in HepaRGTM cells, the cell viability studies, and the paired high-throughput CometChip ® analysis were conducted at Integrated Laboratory Systems, Inc. (ILS; Research Triangle Park, Durham, NC, USA).

    Techniques: Gene Expression

    Comparison of benchmark concentrations for CometChip ® (BMC CC ) and TGx-DDI biomarker genes (BMC TGx ).

    Journal: Frontiers in Public Health

    Article Title: A Modern Genotoxicity Testing Paradigm: Integration of the High-Throughput CometChip® and the TGx-DDI Transcriptomic Biomarker in Human HepaRG™ Cell Cultures

    doi: 10.3389/fpubh.2021.694834

    Figure Lengend Snippet: Comparison of benchmark concentrations for CometChip ® (BMC CC ) and TGx-DDI biomarker genes (BMC TGx ).

    Article Snippet: The chemical exposures in HepaRGTM cells, the cell viability studies, and the paired high-throughput CometChip ® analysis were conducted at Integrated Laboratory Systems, Inc. (ILS; Research Triangle Park, Durham, NC, USA).

    Techniques: Comparison, Biomarker Discovery

    Relationship between the BMCs of the CometChip ® data (BMC CC ) and the TGx-DDI biomarker genes (BMC TGx ) for the test chemicals that yielded positive hazard calls in both tests and could be modeled. Specifically, the BMC CC with a BMR of 1SD with two-sided 95% CIs are shown for the CometChip ® vs. median bootstrap BMC TGX (BMR of 1SD) with two-sided 95% CIs for the TGx-DDI biomarker classification endpoint. The BMCs for the agents that were classified as DDI from both approaches were within 10-fold. The two parallel black lines with intercepts of 1 and −1 on the double log10 scale represent a 10-fold deviation from the 1:1 line.

    Journal: Frontiers in Public Health

    Article Title: A Modern Genotoxicity Testing Paradigm: Integration of the High-Throughput CometChip® and the TGx-DDI Transcriptomic Biomarker in Human HepaRG™ Cell Cultures

    doi: 10.3389/fpubh.2021.694834

    Figure Lengend Snippet: Relationship between the BMCs of the CometChip ® data (BMC CC ) and the TGx-DDI biomarker genes (BMC TGx ) for the test chemicals that yielded positive hazard calls in both tests and could be modeled. Specifically, the BMC CC with a BMR of 1SD with two-sided 95% CIs are shown for the CometChip ® vs. median bootstrap BMC TGX (BMR of 1SD) with two-sided 95% CIs for the TGx-DDI biomarker classification endpoint. The BMCs for the agents that were classified as DDI from both approaches were within 10-fold. The two parallel black lines with intercepts of 1 and −1 on the double log10 scale represent a 10-fold deviation from the 1:1 line.

    Article Snippet: The chemical exposures in HepaRGTM cells, the cell viability studies, and the paired high-throughput CometChip ® analysis were conducted at Integrated Laboratory Systems, Inc. (ILS; Research Triangle Park, Durham, NC, USA).

    Techniques: Biomarker Discovery